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Ibuprofen (Advil, Motrin) Ibuprofen is the most common and popularly used over-the-counter NSAID. This drug moderately blocks prostaglandins and has a low risk of GI-tract bleeding and irritation of the stomach lining when used in moderate doses, usually 600 mg every 6 hours. Naproxen (Aleve)
For arthritis, you may need to use the gel for up to 7 days on the painful joint to feel the full effect. Depending on why you’re taking diclofenac, you may only need to take it for a short time. For example, if you have a sore back or toothache, you may only need to take diclofenac for 1 or 2 days.
How to use ibuprofen gel, mousse or spray. Gently massage the ibuprofen into the painful area 3 or 4 times a day. Leave at least 4 hours between applications. Most products must not be used more than 4 times in 24 hours. Check the instructions that come with the medicine to see how many times a day you can use it.
Diclofenac (Oral Route) It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects. This medicine may raise your risk of having a heart attack
The FDA has noted the following ibuprofen warnings and naproxen warnings along with similar risks of other NSAIDs: Heart attack and stroke risk increase even with short-term use, and the risk may begin within a few weeks of starting to take an NSAID. The risk increases with higher doses of NSAIDs taken for longer periods of time.
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